Two goals from Erick Cabaco and Borja Mayoral were enough to give Levante a crucial first leg win against Barcelona.
Levante scored there first goal in the 4th minute before doubling the lead 14 minutes later thanks to a Boateng assistance.
Phillipe Coutinho pulled one back in the 85th minute from the penalty spot but Barcelona could not salvage a point from the first leg.
Barcelona’s loss comes barely three weeks after thrashing Levante 5-0 in La Liga that saw Lionel Messi score a hat trick.
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Lionel Messi was however omitted on Thursday night in a much-changed Ernesto Valverde’s line up.
Possession wise Barcelona took charge with 63 percent compared to Levante who had 37 percent.
Coutinho, Dembele and Malcom took charge of Barcelona’s forward with Vidal, Busquets and Alena occupying the midfield.
Miranda, Brandaniz, Murillo and Semedo made up Barcelona’s defense with goalkeeper Gillessen manning the post.
The return leg is scheduled at the Nou Camp on Thursday.