Premier League fourth placed side Arsenal have been paired with Napoli in the Europa League as rivals Chelsea paired with Slavia Prague.
Villareal of Spain take on fellow countryside Valencia with Portuguese side Benfica taking on German side Eintracht Frankfurt.
Arsenal made it to the quarter-final after upsetting a 3-1 defeat at Rennes scoring three goals at the Emirates to win on a 4-3 aggregate on Thursday night.
If Arsenal win then it will Unai Emery’s fourth win having won three consecutive times when he was the coach of Spanish side Sevilla.
Chelsea will book a direct entry into the Champions League come next season if they win this Europa League.
Chelsea currently lie sixth in the Premier League, three points behind Arsenal with a game in hand.
Europa League quarter-final fixture
Arsenal vs Napoli
Villareal vs Valencia
Benfica vs Eintracht Frankfurt
Slavia Prague vs Chelsea