Serie A champions Juventus came from behind to beat Brescia two goals to one in an away fixture.
Brescia took the lead in the fourth minute through Donnarumma before Juventus leveled in the 40th minute thanks to an own goal.
In the second half, the visitors doubled the lead through Pjanic sending them to the top of the table, a point behind Inter Milan.
Italian striker Balotelli made his first appearance for the club even though he wasted some clear chances in the match.
Balotelli had also completed the four-match suspension he received while at Marseille.
Former Arsenal player Aaron Ramsey featured in the game making it the second appearance for the Wales player since joining the club.
Christiano Ronaldo was missing in action having picked an injury.
Inter Milan can, however, go back to the top as they have only played four games and with twelve points.
Napoli lies in the third position with nine points, a point above fourth-placed side AS Roma who has also played four games.
On Tuesday night, Udinese was held to a goalless draw by Hellas Verona who was at home.
Udinese currently lies at position fifteen, two positions behind Verona and a point behind them.