Manchester United were denied three crucial points away to Southampton despite taking an early goal from youngster Daniel James.
James scored a powerful long-range volley after only 10 minutes to give Manchester United hopes of recording a win.
Southampton came stronger in the second half to take advantage of United’s sloppy finishes leading to a superb equalizer.
Jannik Vestergaard rose to meet Kevin Danso’s cross after goalkeeper David De Gea had denied Danny Ings an open goal.
Danso was however sent off following a tackle on Scott McTominay when he had already been yellow booked.
Marcus Rashford and Mason Greenwood were both denied by Southampton keeper Angus Kunn as Ashley Young and Jesse Lingard hitting off target.
United now have only one win in four games having thrashed Chelsea four goals to nil in the opening match of the English Premier League.
They were then held by Wolves before being beaten by Crystal Palace at the Old Trafford.
Juan Matta failed to impress in the midfield as Frenchman Paul Pogba conceded possession as well as fail to complete crucial passes.
Having let go of striker Romelu Lukaku, Solskjaer led side let go the services of former Arsenal forward Alexis Sanchez to Inter Millan.
The draw leaves United at position seven same points as Chelsea and a point behind Arsenal who host Tottenham on Sunday.